Cymbalta

Cymbalta is a is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) prescribed for the treatment of depressive disorder, painful peripheral neuropathy, osteoarthritis, fibromyalgia, and general anxiety disorder. It is currently marketed and sold under the brand names Duzela, Yentreve, Xeristar, and Ariclaim. Warnings have been issued, however, that Cymbalta may increase risk of heart attack, suicide, and paranoid reactions in some patients.

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Cymbalta

What is Cymbalta?

Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) which is able to trigger a change in the activity of serotonin and norepinephrine in a patient’s body. Serotonin is critical to mood regulation as well as pain perception, and norepinephrine monitors how our body biologically responds to stress. Although scientists are not 100% certain how the medication works, they know that Cymbalta is able to successful treat depression, lower pain, and reduce the symptoms of peripheral neuropathy in diabetic patients including pain, numbness, tingling, burning, or weakness in the hands and feet.

Other Uses

Cymbalta is generally used to treat pain and depression, but it has also been approved for painful peripheral neuropathy, osteoarthritis, fibromyalgia, and general anxiety disorder. In Europe it has also been approved for stress urinary incontinence.

Cymbalta Usage and Statistics

Antidepressant medication Cymbalta, which made millions of dollars for Eli Lilly, lost its patent protection in 2013, opening a gaping hole in their product line. The good news for consumers is that they are now able to buy generic prescriptions for the medication from other companies who have been given the rights to sell lower priced copycat medications. Do not feel too sorry for Lilly, who made billions of dollars by selling Cymbalta since it first launched in 2004. Although the company may lose a substantial amount of money, they have already started producing and selling other drugs to fill the gaps. The company acknowledges the loss of the patent will reduce their revenue, but they understand it is part of the life-cycle of drug production. Despite the end of the patent, they believe the drug had an enormous impact on medicine and offered “pain sufferers a non-addictive alternative to opiate painkillers.” The drug was sold to an estimated 60 million people and sales have grown every year since it market introduction.

How Cymbalta Works

Cymbalta has helped millions of patients suffering from depression, but before you take the pills you should find out what it can do to your body. Cymbalta is an SNRI, or a serotonin and norepinephrine reuptake inhibitor, which means that it can affect both serotonin and norepinephrine, two important substances within your central nervous system.Depression may lower the levels of serotonin and norepinephrine which your body naturally produces in the spinal cord and brain. It is this lowering of these critical substances that medical experts believes can negatively affect both your emotional responses and your body’s ability to communicate effectively with certain parts of your brain.

Cymbalta lowers your cells ability to absorb serotonin and norepinephrine, allowing for an increase of these chemicals in your brain. Because Cymbalta can increase both serotonin and norepinephrine it can be used to combat not only major depressive disorder, but it may also help with other side-effects of depression such as aches and pains, fatigue, headache and sleep problems. Cymbalta has also been prescribed for patients who are suffering from diabetic peripheral neuropathic pain and may help these patients by interfering with the pain receptors ability to detect aching and burning, numbness, tingling, and pain.

Do you have any signs or symptoms after taking Cymbalta?

  • Not only are doctors concerned about the side-effects of taking Cymbalta, they are also concerned about the side-effects from discontinuing the use of the medication. Talk to your doctor before you decide to stop taking Cymbalta. Common withdrawal side-effects can include the following:
  • Agitation
  • Confusion
  • Fatigue
  • Irritability
  • Depression
  • Feelings of hot and cold
  • Mood swings
  • Feelings of unreality
  • Muscle spasms
  • Diarrhea
  • Nausea
  • Dizziness
  • Flatulence
  • Strange feelings or painful sensations
  • Vivid Dreams
  • Flu-like symptoms
  • Headaches
  • Sweating
  • Drowsiness
  • Insomnia
  • Tremors

No one knows for sure how many millions of Americans suffer with depression but some estimates claim the number could be as high as 1 in 10. Medical experts also claim that most sufferers never receive proper treatment. So who suffers the most? Women tend to have more depression than men and most sufferers are between the ages of 45 to 64. Cymbalta should not be taken by patients who are younger than 24 years of age. Patients should also tell their doctor if they are experiencing any suicidal thoughts, hyperactivity, aggression, hostility, agitation, impulsivity, and restlessness. Patients who have liver disease, epilepsy, glaucoma, seizures, bleeding disorders, history of drug use, or bipolar disorder should also notify their doctor about their condition prior to use. Do not use Cymbalta if you are operating heavy machinery.





Cymbalta Black Box Warnings

  • The Food and Drug Administration (FDA) requires specific drugs to include a Black Box warning which is considered the strictest warning that can be applied to the medication. The purpose of this warning is to provide consumers with information about the most serious side-effects which are associated with a particular drug.The Black Box warning for Cymbalta, as well as other antidepressant medications, includes the increased risk of suicidal thinking and behavior in children, adolescents, and young adults in the short-term. All young users should be monitored closely if they are taking antidepressant therapy medications. Other side-effects of Cymbalta may include but are not limited to the following:
  • Abdominal pain
  • Abnormal dreams
  • Feeling hot and cold
  • Myoclonus
  • Nasopharyngitis
  • Aggression
  • Flushing
  • Nausea
  • Agitation
  • Gait Disturbance
  • Night Sweats
  • Apathy
  • Asthenia
  • Blood cholesterol increase
  • Bruxism
  • Chills
  • Cold sweats
  • Dehydration
  • Dermatitis contact
  • Diarrhea
  • Diplopia
  • Disorientation
  • Dizziness
  • Dry Mouth
  • Dysarthria
  • Dysgeusia
  • Ear pain
  • Ecchymosis
  • Erectile dysfunction
  • Erythema
  • Fatigue

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