What is Depakote?
First sold in 1983 for epilepsy treatment, Depakote is the brand name for sodium divalproex, a compound made of sodium valproate and valproic acid. Depakote was approved for treatment of bipolar disorder in 1995 and migraine headaches in 1996. Manufactured by Abbott Laboratories, the drug can be ingested in a variety of ways including pill, injection, or liquid form. Regardless of the method ingested, Depakote is used to treat certain medical conditions by increasing the GABA (a neurotransmitter) in the brain and helping to reduce voltage sensitive sodium channels.Depakote has been linked to several serious side-effects including pancreatitis, liver toxicity, suicide, and birth defects (cardiovascular malformations, neural tube defects and facial deformities).